Major Depressive Disorder and gut microbiota – Association not causation

Igor Łoniewski, Agata Misera, Karolina Skonieczna-Żydecka, Mariusz Kaczmarczyk, Karolina Kaźmierczak-Siedlecka, Błażej Misiak, Wojciech Marlicz, Jerzy Samochowiec, ‘Major Depressive Disorder and gut microbiota – Association not causation. A scoping review’, https://www.sciencedirect.com/science/article/abs/pii/S0278584620304279, ScienceDirect, Elsevier (23 September 2020)

It was concluded that in MDD, the microbiota is altered. Although the mechanism of this relationship is unknown, we hypothesise that the taxonomic changes observed in patients with MDD are associated with bacterial proinflammatory activity, reduced Schort Chain Fatty Acids (SCFAs) production, impaired intestinal barrier integrity and neurotransmitter production, impaired carbohydrates, tryptophane and glutamate metabolic pathways. (…) We did not observe whether antidepressive medications influence on gut microbiota.

DOI

https://doi.org/10.1016/j.pnpbp.2020.110111