Sleep Deprivation Impairs Molecular Clearance From the Human Brain

Per Kristian Eide, Vegard Vinje, Are Hugo Pripp, Kent-Andre Mardal, Geir Ringstad, ‘Sleep Deprivation Impairs Molecular Clearance From the Human Brain’, https://www.medscape.com/viewarticle/950062, Medscape (Mar 01, 2021)

We provide in vivo evidence that one night of total sleep deprivation impairs molecular clearance from the human brain, an effect not compensated for by another night’s sleep. The results support the hypothesis that the interstitial space increases in the sleeping human brain, as previously demonstrated in rodents. As such, the observations have implications for understanding the impact of disturbed sleep in the evolvement of neurodegenerative disease.