Obesity – an unexplained epidemic

Dariush Mozaffarian, ‘Obesity – an unexplained epidemic’, https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqac075/6572830, The American Journal of Clinical Nutrition, Oxford University Press (23 April 2022)

The commonly accepted explanation is pervasive overeating: ever-increasing energy intake as the population gains weight, year after year. However, evidence does not support this hypothesis. (…) Given the tremendous societal consequences of obesity, and failure to-date of energy balance-focused interventions to stem the tide, it’s critical for the scientific community to consider and test alternative hypotheses. (…) While increasing energy intake may have contributed to rising obesity in earlier years, today pervasive adiposity and its physiologic adaptations have created a biologic milieu which interact with industrialized foods to promote escalating obesity, even with stable energy intake – a self-sustaining, difficult-to-reverse cycle.


Dariush Mozaffarian, Obesity – an unexplained epidemic, The American Journal of Clinical Nutrition, 2022;, nqac075, https://doi.org/10.1093/ajcn/nqac075