Norman A.S. Farb, Philip Desormeau, Adam K. Anderson, Zindel V. Segal, ‘Static and treatment-responsive brain biomarkers of depression relapse vulnerability following prophylactic psychotherapy: Evidence from a randomized control trial’, https://www.sciencedirect.com/science/article/pii/S2213158222000341, https://doi.org/10.1016/j.nicl.2022.102969, ScienceDirect, Elsevier (19 February 2022)
These findings support a two-factor model of depression relapse vulnerability, in which: enduring patterns of dysphoria-evoked sensory deactivation contribute to episode return, but vulnerability may be mitigated by targeting prefrontal regions responsive to clinical intervention. Emotion regulation during illness remission may be enhanced by reducing prefrontal cognitive processes in favor of sensory representation and integration.
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